Delta-sleep inducing peptide, otherwise known as DSIP, is a novel peptide which when injected into the periaqueductal mesoderm of human recipient animals induces delta (or sleep) and spindle (or deep sleep) activity and inhibited motor activity. The amount of peptide injected determines the depth of sleep.
It is believed that you should have delta sleep inducing peptide buy to induce the deepest sleep by blocking off large portion of the cortex and thus selectively slowing down brain wave activity. In addition, this peptide has been shown to be useful in the treatment of psychiatric conditions including depression, obsessive-compulsive disorders, post-traumatic stress disorder, and other anxiety disorders.
The term ‘humoral factors’ is used here, because it refers to those substances and events in life that affect brain development and activity. For example, positive emotional states such as happiness and contentment promote the secretion of certain chemicals called ‘feel good’ and delta activity increases in the gamma band. The levels of these chemicals decrease while negative emotions promote feelings of depression and low confidence, and gamma band activity decreases.
Sleep and circadian rhythms are intimately connected. The relationship between melatonin and the sleep-wakefulness cycle can be understood from recent studies. It has been found that in healthy adults, high concentrations of melatonin in the pinealocytes (cells in the center of the brain responsible for sleep and wakefulness) led to profound reductions in the number of hours of sleep required to achieve a particular level of health.
Melatonin was also found to be effective in reducing the amount of waking after a night of good sleep. While it is not clear how melatonin affects the timing system of our brains, the presence of melatonin in the pinealocytes supports the view that melatonin and other substances known to influence the sleep-wakefulness cycle exist in the brain. It has also been found that the levels of melatonin in the pinealocytes can change as a result of recent stress, and this may play an important role in the development of jet lag.
In addition, the relationship between the substances and the recent environmental changes that we have experienced in the last 50 years can be investigated. Studies have shown that exposure to low levels of some substances can increase the risk of jet lag while at the same time reducing the ability of the body to adjust to external stimuli. A high level of exposure to high levels of noise, chemicals, or other environmental pollutants, however, can have adverse effects on both sleep and wakefulness.
One of the most exciting recent studies looked at the impact of melatonin on the pinealocyte response to light and darkness. It was found that the firing of the cells in the cerebral cortex (the part of the brain responsible for the interpretation of visual information) was much greater when melatonin was present in the environment. This study concluded that melatonin has a very direct effect on the pinealocytes, and that it is this direct effect on the pinealocytes that account for the link between sleep and wakefulness.
The cellular processes that are involved in the process of sleep are in many ways similar to those involved in the production of melatonin. It has also been found that the pinealocytes play an important role in the generation of melatonin, which provides a very deep and interesting link between the sleep and wake disorders.